You're talking about something different from the OP.
I would first find fault with the designation of "designer" humans. Are in vitro fertilized embryos "designer"? After all, these are people which shouldn't exist, their parents are empirically incapable of conceiving children, an intervention has occurred (which kills several fertilized embryos in the process) in order to conceive a child, because of the parents' belief that they are incomplete without children -- it is their wish, their sensibility, their purchase, and not their right or their nature. The child is a plan, a consumer product, alas, only available to the relatively wealthy.
Further, places much less well off than rich US medical clinics already offer "designer" humans, in China and India it's common for mothers to simply cull their female zygotes, they abort them. This is plainly an evil thing, it's bad practically and bad morally. But, how do you prevent it? What steps are you willing to go to to prevent the abortion of "undesirable" zygotes? You can ban abortion, but that only bans it for people that can't buy a plane ticket or have access to "discrete" services, and a lot of people believe they have a right to have abortions. The government could examine all expectant mothers and license abortions, forbidding ones that meet their politically-correct standard of "by design." Of course, that designation is up for debate, and something like malaria susceptibility might or might not be defect dependent on local conditions, the "luck" of such a trait given their parents genotype.
And then, we're not just talking about giving people glowing ears or racing stripes, we're also talking about making sure they'll never contract HIV, or the plague, or congenital blindness. What do you tell someone who's born with an abnormality? "Sorry, but our advanced moral consciousness demands that you be born blind, because it would be a violation of human dignity for you not to be"? Why are genotypic changes such a big deal, but phenotypic modifications, like vaccines, not a "violation of human dignity"? Is it a violation of human dignity that I'm immune to measles, because I grew up rich and white in the western world, while a billion Africans are not?
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